Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/147863
Title: DEPOSITION OF CHEMICALLY-MODIFIED APATITES AS COATINGS FOR BIOMEDICAL APPLICATIONS
Authors: QIU XIHE
Keywords: Antibacterial, Bioactivity, Bone, Coating, Drop-on-Demand, Hydroxyapatite
Issue Date: 25-Jun-2018
Citation: QIU XIHE (2018-06-25). DEPOSITION OF CHEMICALLY-MODIFIED APATITES AS COATINGS FOR BIOMEDICAL APPLICATIONS. ScholarBank@NUS Repository.
Abstract: As a popular bone replacement material, hydroxyapatite (HA) has limitations such as slow osseointegration rate and weak host defense capability, making it susceptible to implant-related infections. The substitution of silicon (Si) would enhance the osseointegration rate whilst the substitution of silver (Ag) would create antibacterial properties. To facilitate bone growth and reduce bacterial adhesion simultaneously, multi-material coatings composed of SiHA and AgHA at ratios of 1:1, 1:2, 1:3 (1SiHA-1AgHA, 1SiHA-2AgHA, 1SiHA-3AgHA) were fabricated by different coating patterns via Drop-on-Demand (DoD) micro-dispensing technique. 1SiHA-3AgHA coatings demonstrated an inhibition on the growth of Escherichia coli for up to 24 h, with significantly less bacteria adhesion compared to HA and SiHA coatings. The biological response of adipose-derived mesenchymal stem cells (hASCs) cultured on 1SiHA-3AgHA coatings exhibited enhanced cell attachment, proliferation and differentiation. Hence, DoD micro deposition technique could be potentially used in producing multi-material coatings for biomedical applications.
URI: http://scholarbank.nus.edu.sg/handle/10635/147863
Appears in Collections:Ph.D Theses (Open)

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