Please use this identifier to cite or link to this item: https://doi.org/10.1039/c1ob06116j
Title: A heterogeneous Pd-Bi/C catalyst in the synthesis of l-lyxose and l-ribose from naturally occurring d-sugars
Authors: Fan, A.
Jaenicke, S. 
Chuah, G.-K. 
Issue Date: 26-Oct-2011
Source: Fan, A.,Jaenicke, S.,Chuah, G.-K. (2011-10-26). A heterogeneous Pd-Bi/C catalyst in the synthesis of l-lyxose and l-ribose from naturally occurring d-sugars. Organic and Biomolecular Chemistry 9 (22) : 7720-7726. ScholarBank@NUS Repository. https://doi.org/10.1039/c1ob06116j
Abstract: A critical step in the synthesis of the rare sugars, l-lyxose and l-ribose, from the corresponding d-sugars is the oxidation to the lactone. Instead of conventional oxidizing agents like bromine or pyridinium dichromate, it was found that a heterogeneous catalyst, Pd-Bi/C, could be used for the direct oxidation with molecular oxygen. The composition of the catalyst was optimized and the best results were obtained with 5:1 atomic ratio of Pd:Bi. The overall yields of the five-step procedure to l-ribose and l-lyxose were 47% and 50%, respectively. The synthetic procedure is advantageous from the viewpoint of overall yield, reduced number of steps, and mild reaction conditions. Furthermore, the heterogeneous oxidation catalyst can be easily separated from the reaction mixture and reused with no loss of activity. © 2011 The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/75423
ISSN: 14770520
DOI: 10.1039/c1ob06116j
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